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KMID : 1059519980420010092
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Journal of the Korean Chemical Society
1998 Volume.42 No. 1 p.92 ~ p.98
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Synthesis of Poly(DL-lactide-co-glycolide) Copolymers and Its Application (I). Release Characteristics of Clonazepam Using Poly(DL-lactide-co-glycolide) (80:20) Copolymers
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Nah Jae-Woon
Lee Dong-Byung
Cho Chong-Su
Jeong Young-Il
Kim Sung-Ho
Kim Sung-Hyun
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Abstract
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Poly(DL-lactide-co-glycolide) (80:20) was synthesized from DL-lactide and glycolide, and the copolymers was made to micelles containing clonazepam for drug delivery system. The release experiments of the drug from micelles were operated at pH 7.4 phosphate buffer solution 37.0±0.05 ℃. The linearly-releasing time ranges of the drug from micelles prepared with the copolymer/drug weight ratio of 20:40, 20:20, and 40:20 (mg) were 50, 41, and 20 days, respectively. So the linearly-releasing time of drug showed the order of micelles 20/40 > micelles 20/20 > micelles 40/20. In short, the formulation allows polymeric micelles to suppress the burst effect of the drug release mechanism, which led to the controlled release pattern and the possibility of drug delivery system for veinous injection.
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